MarsEdit works great with Micro.blog, and includes a number of features specifically targeting the platform.
Configuring MarsEdit for Micro.blog
If you don’t already have your Micro.blog configured in MarsEdit, check out the Micro.blog help page on using MarsEdit. The main thing to know is that you will need to generate a token for MarsEdit to use in lieu of a “password”. Once you have that token, just add the blog in MarsEdit by supplying your blog’s home page. MarsEdit will handle the rest!